阿基瑞琳阿基瑞林乙酰基六肽-8CAS: 616204-22-9原料供应发货仅供科研试验

发布：2023-09-18 14:27，更新：2024-11-24 08:00

中文名	阿基瑞林
英文名	Argireline
别名	阿基瑞琳阿基瑞林阿基瑞林原液乙酰基六肽-8 美容肽-阿基瑞林 ARGIRELINEACETATE (ACETYLHEXAPEPTIDE-3)
英文别名	Reproage Argireline Anti-Wrinkle Multi-Peptides Ac-Glu-Glu-Met-Glu-Arg-Arg-NH2 Argireline,Acetyl hexapeptide-3, BR N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide Argireline acetate Ac-Glu-Glu-Met-Arg-Arg-NH2
CAS	616204-22-9
EINECS	1592732-453-0
化学式	C34H60N14O12S
分子量	889
InChI	InChI=1/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
InChIKey	RJZNPROJTJSYLC-LLINQDLYSA-N
密度	1.54
溶解度	water soluble
折射率	1.66
酸度系数	4.43±0.10(Predicted)
存储条件	-20°C
外观	lyophilized solid
颜色	white
体外研究	The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC 50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC 50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration.
体内研究	Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.