非罗考昔CAS: 189954-96-9原料研发生产仅供科研实验
更新时间：2024-11-09 08:00:00
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详细介绍
| 中文名 | Firocoxib |
| 英文名 | Firocoxib |
| 别名 | 非罗考昔 非罗考昔溶液, 100PPM 3-(环丙基甲氧基)-5,5-二甲基-4-[4-(甲基磺酰基)苯基]-2(5H)-呋喃酮 |
| 英文别名 | Equixx Librens Equioxx FIROCOXIB Firocoxib ML 1785713 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2- one 2(5H)-Furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl- 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone |
| CAS | 189954-96-9 |
| EINECS | 200-001-2 |
| 化学式 | C17H20O5S |
| 分子量 | 336.4 |
| 密度 | 1.31 |
| 熔点 | 78-80°C |
| 沸点 | 563.9±50.0 °C(Predicted) |
| 溶解度 | 氯仿 (微溶) 、乙酸乙酯 (微溶) 、甲醇 (微溶) |
| 存储条件 | Sealed in dry,Store in freezer, under -20°C |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 体外研究 | The COX-1:COX-2 selectivity ratios generally are established by comparing the IC 50 for COX-1 to the IC 50 for COX-2. The IC 80 value more closely resembles the steady-state plasma drug concentration than does the IC 50 value.The selectivity ratio for Firocoxib based on the IC 80 values is 121 (IC 80 of 0.36 μM and 43.6 μM for COX-2 and COX-1, respectively), indicating that selectivity for COX-2 is not reduced at concentrations higher than the IC 50 . Notably, Firocoxib concentrations that yield 80% to 95% inhibition of COX-2 produce < 20% inhibition of COX-1. |
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