辛伐他汀铵盐 辛伐他汀酸铵盐CAS: 139893-43-9原料生产供应仅供企业出口
更新时间：2025-01-30 08:00:00
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详细介绍
| 中文名 | (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵 |
| 英文名 | Simvastatin ammonium salt |
| 别名 | 辛伐他汀铵盐 辛伐他汀酸铵盐 辛伐他汀羟酸铵盐 辛伐他汀开环铵盐 辛伐他汀乙酸铵盐 辛伐他汀羟基酸铵盐 辛伐他汀杂质01(NH3) (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵 |
| 英文别名 | Simvastatin impurity A Simvastatin ammonium salt SIMVASTATIN AMMONIUM SALT Simvastatin acid ammonium salt SIMVASTATIN HYDROXY ACID, AMMONIUM SALT Simvastatin hydroxyl acid ammonium salt 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)- (9CI) |
| CAS | 139893-43-9 |
| EINECS | 1533716-785-6 |
| 化学式 | C25H43NO6 |
| 分子量 | 453.61 |
| 熔点 | 128-131°C |
| 水溶性 | 3.3g/L at 20℃ |
| 蒸汽压 | 0.001Pa at 25℃ |
| 溶解度 | DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly) |
| 存储条件 | -20°C |
| 外观 | Solid |
| 颜色 | White to Off-White |
| BRN | 4836426 |
| 体外研究 | There is a pH-dependent effect on organic anion transporting polypeptide 3A1 (OATP3A1) uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene. The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells. |
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