低分子肝素 盐酸甲哌卡因 盐酸卡波卡因CAS: 1722-62-9原料供应仅供出口
更新时间：2024-05-18 07:00:00
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详细介绍
| 中文名 | 盐酸卡波卡因 |
| 英文名 | mepivacaine hydrochloride |
| 别名 | 低分子肝素 盐酸甲哌卡因 盐酸卡波卡因 甲哌卡因杂质B 甲哌卡因盐酸盐 盐酸甲哌卡因(碱基) 盐酸甲哌卡因?, BR 盐酸甲哌卡因, 局部麻醉, 电压门控NA+通道阻滞剂 N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺盐酸盐 |
| 英文别名 | Mepivacaine HCL Mepivacaine HCl USP carbocainehydrochloride mepivacaine hydrochloride dl-mepivacainehydrochloride Ropivacaine base Mepivacaine HCL Mepivacaine Hydrochloride (200 mg) 1-methyl-2',6'-pipecoloxylididehydrochloride 1-methyl-2',6'-pipecoloxylididehydrochloride 1-methyl-2',6'-pipecoloxylidine hydrochloride dl-1-methyl-2',6'-pipecoloxylididehydrochloride 6'-pipecoloxylidide,1-methyl-2monohydrochloride 2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI) n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride (1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI) |
| CAS | 1722-62-9 |
| EINECS | 217-023-9 |
| 化学式 | C15H22N2O.ClH |
| 分子量 | 282.81 |
| InChI | InChI=1/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H |
| 熔点 | 255-257°C (dec.) |
| 沸点 | 383.1°C at 760 mmHg |
| 闪点 | 185.5°C |
| 蒸汽压 | 4.52E-06mmHg at 25°C |
| 溶解度 | H2O: soluble20mg/mL, clear |
| 存储条件 | 2-8°C |
| 外观 | powder |
| 颜色 | white to beige |
| 体外研究 | Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels. |
| 体内研究 | 对马的测试表明，与根据以前解剖的，乳胶注射后得到的假定相比，mepivacaine在相邻关节结构间具有更大的扩撒，与关节造影研究形成对比。经历膝关节镜检查患者中，与神经刺激相比较，超声处理使1.5% mepivacaine阻断坐骨神经所需的Zui低有效麻醉剂体积(MEAV50)减少37%。在犬齿和前臼齿中，lidocaine制剂与肾上腺素相比，3%mepivacaine的使用使麻醉时间间隔更短。 |
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