食欲肽B (人) 人OREXIN BCAS: 205640-91-1原料药研发供应中间体
更新时间：2024-12-01 08:00:00
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品牌:CRS
型号:CMO
产地:国产
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详细介绍
| 中文名 | 食欲肽B (人) |
| 英文名 | OREXIN B (HUMAN) |
| 别名 | 食欲肽B (人) 人OREXIN B |
| 英文别名 | HYPOCRETIN-2 OREXIN B (HUMAN) HYPOCRETIN-2, HUMAN Orexin B (huMan)Hypocretin-2 (huMan) ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 |
| CAS | 205640-91-1 |
| 化学式 | C123H212N44O35S |
| 分子量 | 2899.34 |
| 存储条件 | -20°C |
| 体外研究 | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively. |
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