盐酸伊伐布雷盐酸伊伐布雷定盐酸依伐布雷定盐酸伊伐布雷啶CAS: 148849-67-6原料研发供应

更新时间：2025-01-30 08:00:00

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详细介绍

中文名	盐酸依伐布雷定
英文名	Ivabradine hydrochloride
别名	盐酸伊伐布雷盐酸伊伐布雷定盐酸依伐布雷定盐酸伊伐布雷啶盐酸依法布雷定依伐布雷定盐酸盐盐酸伊伐布雷定及中间体盐酸伊伐布雷定(依法布雷定) 盐酸伊伐布雷定IVABRADINE(研发中) 3-[3-[[(8S)-3,4-二甲氧基-8-双环[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,5-二氢-1H-3-苯并氮杂卓-4-酮盐酸盐
英文别名	Corlentor Ivabradine HCl Ivabradine hydrochloride IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
CAS	148849-67-6
EINECS	638-798-3
化学式	C27H36N2O5.HCl
分子量	505.05
InChI	InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1
InChIKey	HLUKNZUABFFNQS-ZMBIFBSDSA-N
熔点	193-196?C
沸点	626.9°C at 760 mmHg
比旋光度	58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
闪点	332.9°C
蒸汽压	1.24E-15mmHg at 25°C
溶解度	H2O: ≥5mg/mL (warmed)
存储条件	2-8°C
外观	powder
颜色	white to beige
Merck	14,5247
MDL号	MFCD00929899
体内研究	Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension.