大环哌喃他克莫斯泰克利马他克莫司CAS: 104987-11-3原料仅供出口或科研试验

更新时间：2024-12-02 08:00:00

价格：请来电询价

品牌:CRS

型号:CMO

产地:国产

联系电话：0571-87428035

联系手机： 15360676961

联系人：Allen

让卖家联系我

详细介绍

中文名	大环哌喃
英文名	Tacrolimus
别名	大环哌喃他克莫斯泰克利马他克莫司他可莫司他克莫司标准品他克莫司FK-506 他可莫司(FK506)
英文别名	FK-506 L 679934 Protopic Tacrolimus Tacarolimus ,19s,26ar))- Fujimycin Prozraf 16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1 3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12, (2-propenyl)-,(3s-(3r(e(1s,3s,4s)),4s,5r,8s,9e,12r,14r,15s,16r,18s (3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone (3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R[E(1S,3S,4S)],4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR]]-
CAS	104987-11-3
EINECS	1308068-626-2
化学式	C44 H69 N O12
分子量	804.02
InChI	InChI=1/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19-,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChIKey	QJJXYPPXXYFBGM-LFZNUXCKSA-N
密度	1.19±0.1 g/cm3(Predicted)
熔点	113-115°C
沸点	871.7±75.0 °C(Predicted)
比旋光度	-84.4 (c, 1.02 in CHCl3)
闪点	2℃
水溶性	Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
蒸汽压	1.73E-35mmHg at 25°C
溶解度	DMSO: >3mg/mL
折射率	1.549
酸度系数	9.97±0.70(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
稳定性	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
外观	solid
颜色	white
物化性质	单水合物：C44H69NO12?H2O。从乙腈中得无色棱状结晶，熔点127～129℃。[α] D20-84.4°(C=1.02，氯仿)。溶于甲醇、乙醇、丙酮、乙酸乙酯、氯仿或yimi，难溶于己烷或石油醚，不溶于水。急性毒性LD50小鼠(mg／kg)：＞200腹腔注射。急性毒性LD50雄、雌大鼠(mg/kg)：57．0，23.6静脉注射；134，194口服。