坎格列净 CAS: 842133-18-0;928672-86-0原料供应实验室发货

更新时间：2024-11-29 08:00:00

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详细介绍

中文名	坎格列净
英文名	canagliflozin
别名	坎格列净卡格列净卡格列净半水卡格列净半水物坎格列嗪半水物卡格列净无水物卡格列净半水合物坎格列净(半水) 坎格列净半水合物坎格列净半水化合物坎格列净半水合物(坎格列净) (1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇
英文别名	Cageline canagliflozin Cagliflozin heMihydrate Canagliflozin heMihydrate Canagliflozin heMihydrates 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate
CAS	842133-18-0 928672-86-0
EINECS	202-303-5
化学式	2(C24H25FO5S).H2O
分子量	462.53
密度	1.4±0.1 g/cm3
熔点	94-96°C
沸点	642.9±55.0 °C at 760 mmHg
闪点	342.6±31.5 °C
溶解度	DMSO (Slightly), Methanol (Slightly)
存储条件	Hygroscopic, Refrigerator, under inert atmosphere
稳定性	Hygroscopic
外观	Solid
颜色	White to Off-White
MDL号	MFCD18251436
体外研究	Canagliflozin inhibits Na + -dependent 14 C-AMG uptake in CHO-hSGLT2 cells, with an IC 50 of 4.4±1.2 nM. Similar IC 50 values are obtained in CHO-rSGLT2 and CHO-mSGLT2 cells (IC 50 = 3.7 and 2.0 nM for rat and mouse SGLT2, respectively). Canagliflozin inhibits 14 C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC 50 of 684±159 nM and >1,000 nM, respectively.
体内研究	Canagliflozin (30 mg/kg treatment for 4 weeks) reduced blood glucose (BG) levels, respiratory exchange ratio, and body weight gain in DIO mice. Canagliflozin (3 mg/kg for 3 weeks) increases urinary glucose excretion (UGE) with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight In ZF rats. Animal Model: Diet-induced obese, insulin resistantmice (DIO) Mice Dosage: 30 mg/kg Administration: Oral gavage; daily; 4 weeks Result: Reduced BG levels, respiratory exchange ratio, and body weight gain. Animal Model: Male Zucker fatty (ZF) obese, insulin resistant rats Dosage: 3 mg/kg Administration: Oral gavage; daily; 3 weeks Result: UGE was increased with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight.