雄酮(Androsterone) CAS: 53-41-8甾体激素供应发货

更新时间：2024-11-30 08:00:00

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型号:CMO

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详细介绍

中文名	雄酮
英文名	Androsterone
别名	雄酮雄(甾)酮雄甾酮,雄酮,雄性酮 3-羟基雄烷-17-酮 3α-羟基-5α-雄甾烷-17-酮表雄酮,雄甾酮,3Α-羟基-5Α-雄甾烷-17-酮 (8R,9S,10S,13S,14S)-3-羟基-10,13-二甲基-1,2,3,4,5,6,7,8,9,11,12,14,15,16-十四氢环戊烷并[A]菲-17-酮
英文别名	Androsterone cis-Androsterone 3alpha-Hydroxy-17-androstanone 3-alpha-hydroxy-17-androstanone 3-Epihydroxyetioallocholan-17-one (3alpha)-3-hydroxyandrostan-17-one 3alpha-Hydroxy-5alpha-androstan-17-one 5-alpha-Androstan-3 alpha-ol-17-one-16 3-alpha-hydroxy-5-alpha-androstan-17-on 3-alpha-hydroxy-5-alpha-androstan-17-one (3β,8xi,9xi,14xi)-3-hydroxyandrostan-17-one 3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on 3-hydroxy-10,13-dimethylperhydrocyclopenta[a]phenanthren-17-one (3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
CAS	53-41-8
EINECS	200-173-4
化学式	C19H30O2
分子量	290.44
InChI	InChI=1/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12?,13-,14?,15?,16?,18-,19-/m0/s1
密度	1.0320 (rough estimate)
熔点	181-184°C(lit.)
沸点	372.52°C (rough estimate)
比旋光度	96 º (c=1, C2H5OH)
闪点	176.4°C
水溶性	11.5mg/L(23.5 ºC)
蒸汽压	1.5E-08mmHg at 25°C
折射率	1.4709 (estimate)
酸度系数	15.14±0.60(Predicted)
存储条件	−20°C
外观	neat
Merck	13,645
BRN	2217626
体外研究	Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
体内研究	Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).