actide/ACTH (1-39 丝拉克肽 12279-41-3原料药供应发货工厂直发
发布：2024-02-29 10:56，更新：2024-05-05 07:00
丝拉克肽（Saralasin）是一种合成的肽类化合物，也被称为AII拮抗剂，它能与血管紧张素II（Angiotensin II，简称AII）受体结合并阻止AII的作用。
丝拉克肽的化学结构是由10个氨基酸组成的肽链。它主要用于研究AII系统的生理功能和疾病治疗。它可以用于治疗高血压、心力衰竭和肾脏疾病等与AII系统有关的疾病。
丝拉克肽的合成通常采用固相肽合成法。它可以通过合成AII肽链时，在合成过程中引入一些结构变化，如酰化或氨基酰化等方式来制备。合成的过程相对复杂，需要具备合成有机化学的基础知识和实验技能。
| 中文名 | 丝拉克肽 |
| 英文名 | Adrenocorticotropic hormone fragment 1-39 |
| 别名 | 丝拉克肽 六氟硅酸 人ACTH (1-39)肽 促肾上腺皮质激素(1-39) |
| 英文别名 | CORTICOTROPHIN CORTICOTROPIN A Seractide acetate CORTICOTROPIN (HUMAN) ACTH (1-39) (huMan)Corticotropin Adrenocorticotropic Hormone (ACTH) (1-39) Adrenocorticotropic hormone fragment 1-39 Adrenocorticotropic Hormone (ACTH) (1-39), human H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH |
| CAS | 12279-41-3 |
| EINECS | 634-154-0 |
| 化学式 | C207H308N56O58S1 |
| 分子量 | 4541.07 |
| 溶解度 | H2O: 1mg/ml，澄清，无色 |
| 存储条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 外观 | 固体 |
| 物化性质 | 类白色粉末,有特臭。 |
| MDL号 | MFCD00145721 |
| 体外研究 | Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS. |
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