actide/ACTH (1-39 丝拉克肽 12279-41-3原料药供应发货工厂直发

发布：2024-02-29 10:56，更新：2024-11-24 08:00

丝拉克肽（Saralasin）是一种合成的肽类化合物，也被称为AII拮抗剂，它能与血管紧张素II（Angiotensin II，简称AII）受体结合并阻止AII的作用。

丝拉克肽的化学结构是由10个氨基酸组成的肽链。它主要用于研究AII系统的生理功能和疾病治疗。它可以用于治疗高血压、心力衰竭和肾脏疾病等与AII系统有关的疾病。

丝拉克肽的合成通常采用固相肽合成法。它可以通过合成AII肽链时，在合成过程中引入一些结构变化，如酰化或氨基酰化等方式来制备。合成的过程相对复杂，需要具备合成有机化学的基础知识和实验技能。

中文名	丝拉克肽
英文名	Adrenocorticotropic hormone fragment 1-39
别名	丝拉克肽六氟硅酸人ACTH (1-39)肽促肾上腺皮质激素(1-39)
英文别名	CORTICOTROPHIN CORTICOTROPIN A Seractide acetate CORTICOTROPIN (HUMAN) ACTH (1-39) (huMan)Corticotropin Adrenocorticotropic Hormone (ACTH) (1-39) Adrenocorticotropic hormone fragment 1-39 Adrenocorticotropic Hormone (ACTH) (1-39), human H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH
CAS	12279-41-3
EINECS	634-154-0
化学式	C207H308N56O58S1
分子量	4541.07
溶解度	H2O: 1mg/ml，澄清，无色
存储条件	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
外观	固体
物化性质	类白色粉末,有特臭。
MDL号	MFCD00145721
体外研究	Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.

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