硫酸阿米卡星阿米卡霉素硫酸CAS: 149022-22-0原料仅供出口或科研试验

发布：2023-09-04 10:13，更新：2024-05-07 07:00

中文名	硫酸阿米卡星
英文名	amikacin sulfate
别名	硫酸阿米卡星阿米卡霉素硫酸磺胺甲恶唑149022-22-0 硫酸阿米卡星149022-22-0
英文别名	AMIKASIN SULFATE liusuanamukaxonm amikacin sulfate Amikacin Sulfate Salt Amikacin sulfate salt mikacin disulfate salt AMIKACIN SULFATE SALT, AMINOGLYCOSID (2R)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt)
CAS	149022-22-0
EINECS	254-648-6
化学式	C22H45N5O17S
分子量	683.68
InChI	InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
InChIKey	HIBICIOPDUTNRR-BOEHXBESSA-N
熔点	220-230℃
沸点	1102.4°C at 760 mmHg
闪点	620.5°C
蒸汽压	0mmHg at 25°C
溶解度	H2O: soluble50mg/mL
存储条件	Inert atmosphere,2-8°C
外观	solid
颜色	white to off-white
MDL号	MFCD00167475
体外研究	Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ). Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD 50 value of 453 μM.