罗沙司他 洛度司他 罗沙司他光降解杂质CAS: 808118-40-3原料药研发供应中间体
| 中文名 | N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]甘氨酸 |
| 英文名 | FG-4592 |
| 别名 | 罗沙司他 洛度司他 罗沙司他光降解杂质 HIF脯氨酰羟化酶抑制剂(FG-4592) N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉)羰基]甘氨酸 N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]甘氨酸 甘氨酸, N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]- FG4592 N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉)羰基]甘氨酸 |
| 英文别名 | FG-4592 FG-4592(ASP1517) N-[(4-Hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine Glycine, N-[(4-hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- 2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid 2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID [[(4-Hydroxy-1-Methyl-7-phenoxyisoquinolin-3-yl)carbonyl]aMino]acetic Acid [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid |
| CAS | 808118-40-3 |
| EINECS | 813-400-2 |
| 化学式 | C19H16N2O5 |
| 分子量 | 352.34 |
| InChI | InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23) |
| 密度 | 1.389 |
| 熔点 | 199-215°C |
| 沸点 | 684.3±55.0 °C(Predicted) |
| 溶解度 | Soluble in DMSO (up to at least 25 mg/ml). |
| 酸度系数 | 2.46±0.10(Predicted) |
| 存储条件 | -20°C |
| 稳定性 | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| 外观 | solid |
| 颜色 | Off-white or white |
| 体外研究 | FG-4592是一种口服缺氧诱导因子（HIF）脯氨酰羟化酶抑制剂,在临床上用于治疗贫血。FG-4592稳定HIF的活动，HIF是细胞内转录因子，导致与红细胞相关基因，包括EPO，和参与铁代谢相关酶的激活。 |
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