Abarelix 阿巴瑞克 183552-38-7原料供应仅供科研 冻干工艺 可发货
| 中文名 | Abarelix |
| 英文名 | Abarelix |
| 别名 | 巴瑞克 阿巴瑞克 醋酸阿巴瑞克 阿巴瑞克乙酸盐 醋酸阿巴瑞克 183552-38-7 ABARELIX ACETATE 阿巴瑞克及杂质对照品 |
| 英文别名 | R 3827 PPI-149 Plenaxis Abarelix Abarelix Acetate Abarelix Acetate(Plenaxis) Ac-DNal-DCpa-DPal-Ser-NαMeTyr-DAsp-Leu-Ilys-Pro-DAl-NH2 D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- |
| CAS | 183552-38-7 |
| EINECS | 1592732-453-0 |
| 化学式 | C72H95ClN14O14 |
| 分子量 | 1416.06 |
| 密度 | 1.286±0.06 g/cm3(Predicted) |
| 沸点 | 1688.4±65.0 °C(Predicted) |
| 酸度系数 | 9.82±0.15(Predicted) |
| 存储条件 | -20°C |
| 体外研究 | Abarelix (30 and 300 µg/mL) causes significantly increased histamine release. Abarelix is the firstGnRH antagonist to be developed, and can produce rapid and sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, and with a very low complication rate in the short term. Abarelix demonstrates to promptly and substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, and produces medical castration more quickly. |
| 上游原料 | 三氟乙酸 N,N-二异丙基乙胺 |
盐酸奈必洛尔原料-多肽GLP-1原料-睾酮激素甾体-南京辰瑞晟生物医药科技公司，
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