iRGD iRGD 1392278-76-0多肽原料研发生产西林瓶EP管包装发货
| 中文名 | iRGD |
| 英文名 | iRGD |
| 别名 | 化合物IRGD PEPTIDE 肿瘤多肽H-CYS-ARG-GLY-ASP-LYS-GLY-PRO-ASP-CYS-OH |
| 英文别名 | iRGD iRGD TFA c(CRGDKGPDC) iRGD peptide TFA salt L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide |
| CAS | 1392278-76-0 |
| 化学式 | C35H57N13O14S2 |
| 分子量 | 948.04 |
| 密度 | 1.68±0.1 g/cm3(Predicted) |
| 酸度系数 | 2.92±0.70(Predicted) |
| 存储条件 | Room Temprature |
| 体外研究 | iRGD peptide-mediated tumor penetration occurs in three steps: binding to αv-integrins on tumor vasculature or tumor cells, exposure by proteolysis of a C-terminal motif that binds to neuropilin-1 (NRP-1) and cell internalization. iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells, which express NRP-1 and integrins. iRGD insertion does not impair virus infection and replication. iRGD peptide alone has no obvious effect on gastric cancer cells, and when combined with 5-FU, iRGD peptide (0.3 μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1. |
| 体内研究 | iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells. |
盐酸奈必洛尔原料-多肽GLP-1原料-睾酮激素甾体-南京辰瑞晟生物医药科技公司，
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