P物质(SUBSTANCE P) CAS: 33507-63-0多肽原料保护氨基酸工厂研发生产
| 中文名 | P物质 |
| 英文名 | SUBSTANCE P |
| 别名 | 神经肽 P物质 物质 P 多肽物质P 神经肽H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
| 英文别名 | SUBSTANCE P SUBSTANCE P BOVINE SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE) SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide |
| CAS | 33507-63-0 |
| EINECS | 251-545-8 |
| 化学式 | C63H98N18O13S |
| 分子量 | 1347.63 |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 熔点 | 148 °C |
| 水溶性 | Soluble in water, DMSO, and Acetic Acid. |
| 溶解度 | H2O: 1 mg/mL |
| 酸度系数 | 13.26±0.46(Predicted) |
| 存储条件 | −20°C |
| 外观 | 粉末 |
| 颜色 | white |
| 物化性质 | 白色冷冻干燥粉末，易溶于水，高纯度的水溶液极易失活，加入吐温80、明胶、人血浆白蛋白或牛丙种球蛋白可增加其稳定性；pH大于8时不稳定，遇胃蛋白酶和胰凝乳蛋白酶失活；宜保存于低pH值中，并充氮气或加入抗氧化剂以避免其失活。 |
| 体外研究 | The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells. |
盐酸奈必洛尔原料-多肽GLP-1原料-睾酮激素甾体-南京辰瑞晟生物医药科技公司，
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