teriparatideCAS：12583-68-5小包装西凌瓶产品CSO发货原料厂家
| 中文名 | 牛甲状旁腺激活素-(1-34) |
| 英文名 | PARATHYROID HORMONE (1-34), BOVINE |
| 别名 | 特立帕肽-多肽原料委托生产 特立帕肽-多肽制剂一致性评价 牛甲状旁腺激素-(1-34) 牛甲状旁腺激活素-(1-34) PHT激活剂(TERIPARATIDE) 受体激动剂多肽PARATHYROID HORMONE(1-34) BOVINE |
| 英文别名 | BPTH 1-34 TERIPARATIDE PTH (1-34) (BOVINE) PARATHYROID HORMONE (1-34), BOVINE AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE H-ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OH ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE BOVINE |
| CAS | 12583-68-5 |
| 化学式 | C183H288N54O50S2 |
| 分子量 | 4108.71 |
| 存储条件 | −20°C |
| 外观 | 粉末 |
| 体外研究 | Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group. Cell Proliferation Assay Cell Line: MC3T3-E1 cells Concentration: 0.1-100 ng/mL Incubation Time: 2-20 days Result: Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. |
| 体内研究 | Parathyroid Hormone (1-34)(subcutaneousinjection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals.Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls. |
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