咳平盐酸盐 盐酸氯哌丁 盐酸氯哌斯丁 盐酸氯哌斯汀CAS: 14984-68-0吨位出货优势供应
| 中文名 | 盐酸氯哌斯汀 |
| 英文名 | cloperastine hydrochloride |
| 别名 | 咳平盐酸盐 盐酸氯哌丁 盐酸氯哌斯丁 盐酸氯哌斯汀 氯哌斯汀盐酸盐 盐酸氯哌丁(咳平) CLOPERASTINE HYDROCHLORIDE 氯哌斯汀盐酸盐 |
| 英文别名 | Seki ht11 hustazol UNII-PI4N7C63ND Cloperastine HCl cloperastinacloridrato Cloperastina cloridrato cloperastine hydrochloride CHLOPERASTINE HYDROCHLORIDE Cloperastina cloridrato [Italian] 2-piperidinoethylp-chlorobenzhydryletherhydrochloride 2-Piperidinoethyl p-chlorobenzhydryl ether hydrochloride 4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE 1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato 1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)piperidinium chloride 1-(2-((4-Chlorophenyl)(Phenyl)Methoxy)Ethyl)Piperidine Hydrochloride 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride 1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine hydrochloride 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato [Italian] Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-, hydrochloride Piperidine, 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-, hydrochloride (9CI) |
| CAS | 14984-68-0 |
| EINECS | 239-067-8 |
| 化学式 | C20H25Cl2NO |
| 分子量 | 366.32 |
| InChI | InChI=1/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H |
| 熔点 | 147.9° |
| 沸点 | 423.9°C at 760 mmHg |
| 闪点 | 210.2°C |
| 蒸汽压 | 2.15E-07mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 存储条件 | Inert atmosphere,Room Temperature |
| 外观 | 整洁 |
| 颜色 | White to Off-White |
| Merck | 14,2395 |
| 体外研究 | Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects. |
| 体内研究 | In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively. |
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