克卓替尼 克唑替尼 可唑替尼CAS: 877399-52-5原料生产供应仅供企业出口
| 中文名 | 克里唑蒂尼 |
| 英文名 | 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine |
| 别名 | 克卓替尼 克唑替尼 可唑替尼 克里唑啼尼 克里唑替尼 克里唑蒂尼 CRIZO锡IB C-MET和ALK抑制剂(CRIZOTINIB) 3-[1-(2,6-二氯-3-氟-苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺 (R)-3-(1-(2,6-二氯-3-氟苯基)乙氧基)-5-(1-(哌啶-4-基)-1H-吡唑-4-基)吡啶-2-胺 3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺 |
| 英文别名 | Xalkori PF2341066 Crizotinib Crozotinib Crizotinib Xalkori Crizotinib,PF-02341066 (5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)methanamine 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylaMine 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-aMinopyridine 2-PyridinaMine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine |
| CAS | 877399-52-5 |
| EINECS | 638-814-9 |
| 化学式 | C21H22Cl2FN5O |
| 分子量 | 450.34 |
| InChI | InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 |
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 熔点 | 192 °C |
| 沸点 | 599.2±50.0 °C(Predicted) |
| 闪点 | 316.171°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming) |
| 折射率 | 1.673 |
| 酸度系数 | 9.81±0.10(Predicted) |
| 存储条件 | room temp |
| 稳定性 | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| 外观 | powder |
| 颜色 | white to tan |
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