卡比托辛 卡贝缩宫素CAS: 37025-55-1原料供应仅供出口
| 中文名 | 卡比托辛 |
| 英文名 | Carbetocin |
| 别名 | 卡比托辛 卡贝缩宫素 醋酸卡贝缩宫素 卡贝缩宫素三氟醋酸盐 醋酸卡贝缩宫素,卡比托辛 卡贝缩宫素-多肽原料委托生产 卡贝缩宫素-多肽制剂一致性评价 醋酸卡贝缩宫素 37025-55-1 |
| 英文别名 | Carbetocin CARBETOCIN (BUTYRYL1,TYR(ME)2)-OXYTOCIN CARBETOCIN TRIFLUOROACETATE SALT (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN (BUTYRYL1,TYR(ME)2)-OXYTOCIN TRIFLUOROACETATE SALT (Butyryl1,Tyr(me)2)-1-Carbaoxytocin trifluoroacetate salt (BUTYRYL1,TYR(ME)2)-1-CARBAOXYTOCIN TRIFLUOROACETATE SALT BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 TRIFLUOROACETATE SALT BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDE BOND BETWEEN BUTYRYL-4-YL AND CYS) 1-{[(3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-12-[(2S)-butan-2-yl]-15-(4-hydroxybenzyl)-16-methyl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}-L-prolyl-L-leucylglycinamide glycinamide, 1-[[(3R,6S,9S,12S,15S)-6-(2-amino-2-oxoethyl)-9-(3-amino-3-oxopropyl)-15-[(4-hydroxyphenyl)methyl]-16-methyl-12-[(1S)-1-methylpropyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloeicos-3-yl]carbonyl]-L-prolyl-L-leucyl- |
| CAS | 37025-55-1 |
| EINECS | 253-312-6 |
| 化学式 | C45H69N11O12S |
| 分子量 | 988.17 |
| InChI | InChI=1/C45H69N11O12S/c1-6-25(4)38-44(67)50-28(15-16-34(46)58)40(63)51-30(21-35(47)59)41(64)53-31(23-69-18-8-10-37(61)55(5)33(43(66)54-38)20-26-11-13-27(57)14-12-26)45(68)56-17-7-9-32(56)42(65)52-29(19-24(2)3)39(62)49-22-36(48)60/h11-14,24-25,28-33,38,57H,6-10,15-23H2,1-5H3,(H2,46,58)(H2,47,59)(H2,48,60)(H,49,62)(H,50,67)(H,51,63)(H,52,65)(H,53,64)(H,54,66)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1 |
| 密度 | 1.218±0.06 g/cm3(Predicted) |
| 熔点 | 140 - 160°C |
| 沸点 | 1477.9±65.0 °C(Predicted) |
| 比旋光度 | D -69.0° (c = 0.25 in 1M acetic acid) |
| 闪点 | 846.7°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (Slightly), Methanol (Slightly) |
| 折射率 | 1.541 |
| 酸度系数 | 13.07±0.70(Predicted) |
| 存储条件 | -15°C |
| 稳定性 | Hygroscopic |
| 外观 | powder |
| 颜色 | white to beige |
| 体外研究 | Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (K i =13 nM), E123 (K i =56 nM), and E1234 (K i =37 nM). |
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