盐酸恩诺沙星CAS: 93106-59-3原料供应发货可接受预订单
| 中文名 | 盐酸恩诺沙星 |
| 英文名 | ENROFLOXAIN HYDROCHLORIDE |
| 别名 | 盐酸恩诺沙星 恩诺沙星单盐酸盐 |
| 英文别名 | ENROFLOXAIN HYDROCHLORIDE 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI) |
| CAS | 93106-59-3 |
| EINECS | 274-614-4 |
| 化学式 | C19H23ClFN3O3 |
| 分子量 | 395.8556232 |
| 体外研究 | Mycoplasma bovis is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL. |
| 体内研究 | Mice (n=80) undergo transient middle cerebral artery occlusion (MCAo) with reperfusion after 60 minutes. After MCAo, animals are randomly assigned to receive either a daily preventive medication (n=26, Enrofloxacin) starting at the day of MCAo or a therapeutic medication (n=25; Enrofloxacin) after diagnosis of lung infection. Standard treatment started immediately after the appearance of clinical signs (general health score>6) usually between day 4 and 6 after stroke. Both, preventive and standard antibiotic treatment using Enrofloxacin improve survival in a similar way compared with placebo treatment. |
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