托萘酯(tolnaftate) CAS: 2398-96-1原料供应发货可接受预订单
| 中文名 | N-甲基-N-(3-间甲苯基)硫代氨基甲酸-2-萘酯 |
| 英文名 | tolnaftate |
| 别名 | 托萘酯 托萘酯原料 托萘酸盐杂质 托萘酯(标准品) 托萘酯 USP标准品 托萘酯系统适应性 EP标准品 N-甲基-N-(3-甲基苯基)硫代氨基甲酸-2-萘酯 N-甲基-N-(3-间甲苯基)硫代氨基甲酸-2-萘酯 |
| 英文别名 | Aftate TOLAFTATE tolnaftate Chinofungin O-2-naphthyl N,3-dimethyl(thiocarbanilate) 2-naphthyl n-methyl-n-(3-tolyl)thionocarbamate O-naphthalen-2-yl methyl(3-methylphenyl)carbamothioate Carbanilic acid, m,N-dimethylthio-, O-2-naphthyl ester Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester METHYL 3-TOLYLTHIOCARBAMIC ACID O-NAPHTHALEN-2-YL ESTER O-Naphthalen-2-yl N-methyl-N-(3-methylphenyl)thiocarbamate METHYL-[3-METHYLPHENYL]-CARBAMOTHIOIC ACID O-2-NAPHTHYL ESTER Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester |
| CAS | 2398-96-1 |
| EINECS | 219-266-6 |
| 化学式 | C19H17NOS |
| 分子量 | 307.41 |
| InChI | InChI=1/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3 |
| InChIKey | FUSNMLFNXJSCDI-UHFFFAOYSA-N |
| 密度 | 1.1328 (rough estimate) |
| 熔点 | 110.5-111.5°C |
| 沸点 | 453.4±38.0 °C(Predicted) |
| 闪点 | 228°C |
| 水溶性 | <0.1 g/100 mL at 22 ºC |
| 蒸汽压 | 2.08E-08mmHg at 25°C |
| 溶解度 | Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol |
| 折射率 | 1.6970 (estimate) |
| 酸度系数 | -0.35±0.50(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 敏感性 | Sensitive to heat |
| 外观 | powder |
| 颜色 | white to off-white |
| *大波长(λmax) | ['258nm(MeOH)(lit.)'] |
| Merck | 14,9519 |
| MDL号 | MFCD00056611 |
| 体外研究 | Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid. |
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